Choh Hao Li
(sometimes
Cho Hao Li
) (;
pinyin: L?? Zhu??h??o) (April 21 1913???November 28, 1987) was a Chinese-born U.S. biochemist who discovered, in 1966, that human
pituitary growth
hormone (
somatotropin) consists of a chain of 256
amino acids. In 1970 he succeeded in synthesizing this hormone, the largest protein
molecule
synthesized
up to that time.
Li was born in
Guangzhou and educated at the
Nanjing University. In 1935 he emigrated to the USA, where he took up postgraduate studies at the
University of California at
Berkeley
and later joined the staff. He became professor in 1950. In 1955 he was elected as Academician of
Academia Sinica, Republic of China.
Li spent his entire academic career studying the pituitary-gland hormones. In collaboration with various co-workers, he isolated several protein hormones, including
adrenocorticotropic hormone (ACTH), which stimulates the
adrenal cortex to increase its secretion of
corticoids. In 1956, Li and his group showed that ACTH consists of 39 amino acids arranged in a specific order, and that the whole chain of the natural hormone is not necessary for its action. He isolated another pituitary hormone called
melanocyte-stimulating hormone (MSH) and found that not only does this hormone produce some effects similar to those produced by ACTH, but also that part of the amino acid chain of MSH is the same as that of ACTH.
-
Choh Hao Li Papers
- University of California, San Francisco Library, Archives and Special Collections
-
History of UCSF biography